Yes, you are right, Whipple's disease is rare but not in your MRCP Part 1 and 2 examination. I myself never diagnosed Whipple's disease before but this illness is ceratinly a all time favourite in MRCP examination.
It is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei. First described by George Hoyt Whipple in 1907.
It is one of a important diffential diagnosis of malabsorption syndrome and mainly affect the small bowel. It is more common in those with HLA-B27
Although Whipple's disease primary leads to GIT syndrome ( diarrhoe,weight loss) but for MRCP, patients with Whipple's disease is usually illustrated with symptoms of joint pain!The diagnosis- jejunal biospy with PAS staining.The macrophages stain strongly with PASand contain intracellular bacilli of the bacteria.
Treatment- prolonged antibiotics of penicillin,tetracycline,co-tromoxazole or chrolamphenicol.
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2 comments:
Can you tell me the prerequisites for MRCp Superspeciality certificate test. I have passed my MBBS and MD Internal Medicine (postgraduate degree) from India. Can I write this certificate test and how.
Thanks for sharing an informative blog. Whipple disease is caused due to the infection of bacteria called Tropheryma whippelii. Elongated intake of antibiotics can be the best treatment for the whipple disease. The gastrointestinal system gets affect by this disease. Some of the usual symptoms of the disease are diarrhoea, intestinal bleeding, abdominal pain, loss of appetite, weight loss, fatigue, and weakness
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