Rosiglitazone
Rosiglitazone is a popular drug asked in MRCP examination. It is an aanti-diabetic drug from the thiazolidinedione class. Its mechanism of action is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), Rosiglitazone is ofter referred as 'insulin sensitizer' because it makes the body cells become more sensitive to insulin and remove more glucose from blood.
Indication for Rosiglitazone
Type 2 Diabetes mellitus. It is usually used alone or combined with metformin
Common side effects
It can cause mild to moderate oedema and should be avoided in acute heart failure or severe heart failure patients.
Possibility of liver impairment
Diarrhoe
Headache
Hypo or hyperglycaemia
Common Interaction
Gemfibrozil increases the concentration of rosiglitazone in the blood by reducing its breakdown. Therefore, gemfibrozil may increase the side effects of Rosiglitazone!
Tips for MRCP:
1) Remember about the side effects of Rosiglitazone.
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