Popular Drugs in MRCP- Methotrexate
Today I am going to discuss with you with another popular drug in MRCP. Methotrexate (MTX) is a folic antagonist and also a dihydrofolate reductase inhibitor with potent immunosuppressive activity.
MTX is used in a lot of autoimmune diseases such as Rheumatoid arthritis , vasculitis such as Wegener’s granulomatosis. Certain types of cancer and even in ectopic pregnancy!
Common side effects
Nausea, vomiting
Mucosal ulcer
Hepatotoxicity
Lung fibrosis
Remember that other drugs that can cause lung fibrosis are amiodarone,bulsuphan, bleomycin, nitrofurantoin, hydralazine.
Tips for MRCP
1) Side effect of MTX that is commonly asked in MRCP is lung fibrosis and hepatotoxicity.
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