Thursday, August 17, 2006

Tuberous Sclerosis

Tuberous Sclerosis in MRCP

There are a few conditions that are commonly asked in MRCP Part 1 and 2. These conditions include Tuberous sclerosis (TS), Neurofibromatosis..... etc. I am going to talk about TS today.
TS was discovered in the 1880's by a French physician named Bourneville. Remember that it is an autosomal dominant disease!

There are a few important features of TS, these include,

Facial angiofibroma
periungual fibromas
Hypopigmented macules
Shagreen patch (connective tissue nevus)
Multiple retinal nodular hamartomas
Subependymal nodule ( can be picked up in CT scan as calcification)
Subependymal giant cell astrocytoma
Cardiac rhabdomyoma, single or multiple
Lymphangiomyomatosis
Renal angiomyolipoma

Questions commonly asked in MRCP are photo-based questions, remember these photos.....
1) Periventricular calcification

2) Clinical features of TS


See more photos at www.passpaces.com

Tips for MRCP

1) A patient with recurrent seizure and CT scan shows calcification. Remember TS!

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