Another set of FREE BOFs for MRCP Part 1!

Hope you find all these questions useful.

1)Transcription RNA (tRNA) has three bases specific for a particular amino acid with which it binds to messenger RNA (mRNA). This specific area of tRNA is called the
1 ) anticodon
2 ) codon
3 ) exon
4 ) intron
5 ) transposon



ANSWER: 1

2)The Polymerase Chain Reaction (PCR) is used to amplify small amounts of DNA for further analysis. First the DNA double helix must be split into two strands. This is achieved by
1 ) alkali solution
2 ) centrifugation
3 ) DNA polymerase
4 ) heating to nearly 100°C
5 )viral reverse transcriptase



ANSWER: 4

3)Two strains of Escherichia coli are isolated and both are resistant to ampicillin. Strain A retains its resistance to amplicillin when grown form multiple generations in the absence of ampicillin. However strain B loses its resistance when grown in the absence of ampicillin. Which of the following best explains the loss of antibiotic resistance in strain B?
1 )Changes in the bacterial DNA gyrase
2 )Downregulation of the resistance gene
3 )Loss of a plasmid containing the resistance gene
4 )Mutations in the resistance gene
5 )Transposition of another sequence into the resistance gene



ANSWER: 3

4)A 36 year old male presents with lethargy. He takes no medication and has generally been otherwise well. Examination reveals that he is obese with a BMI of 36.4 kg/m2 and a blood pressure of 120/72. There are no abnormalities of the cardiovascular, respiratory or abdominal systems. Investigations reveal a sodium of 141 mmol/l, a potassium of 2.8 mmol/l, a urea of 5.6 mmol/l and a creatinine of 76 µmol/l. What is the most likely diagnosis.
1 )Conn's syndrome
2 )Apparent mineralocorticoid excess
3 )Cushing's syndrome
4 )Hypokalaemic periodic paralysis
5 )Bartter's syndrome



ANSWER: 5

5)A 52 year old female presents with tiredness. There are no specific abnormalities noted on examination, but investigations reveal a T4 of 21.1 (NR 9.8 - 23), a T3 of 5.2 pmol/l (NR 3.3 - 5.5) and a TSH of 0.05 mU/l (NR 0.1 - 5 mU/l). Thyroid autoantibody titres are all undetectable. These results suggest a diagnosis of
1 )DeQuervain's thyroidits
2 )Sick euthyroid syndrome
3 )Solitary toxic nodule
4 )Graves' disease
5 )Hashimoto's thyroiditis



ANSWER: 3

6)A 32 year old female presents with a 4 month history of amenorrhoea. She takes no specific therapy. She has two children and her husband has has a vasectomy. Examination reveals an obese individual but no other abnormality. Investigations reveal an oestradiol concentration of 100 pmol/l (NR 130 - 500), an LH of 2.1 mU/l (NR 3.0 - 6.6), an FSH of 2.2 mU/l (NR 3.3 - 10.1), a prolactin concentration of 800 mU/l (NR 50 - 500 mU/l) and a testosterone concentration of 2.1 pmol/l (NR less than 3 pmol/l). Which investigation is the most appropriate?
1 )Insulin tolerance test
2 )A Pregnancy test
3 )17 hydroxy-progesterone
4 )Urine free cortisol concentration
5 )A MRI of the pituitary


ANSWER: 5

More questions are coming...............!